What is MARCoNS?
MARCoNS (Multiple Antibiotic Resistant Coagulase Negative Staphylococci) is an antibiotic-resistant staph that resides deep in the nasal passage of 80% of people with low MSH (Melanocyte-Stimulating Hormone), those suffering from Biotoxin Illness and other chronic inflammatory illnesses like CIRS (Chronic Inflammatory Response Syndrome) and CFIDS (Chronic Fatigue and Immune Dysfunction Syndrome).
This percentage increases when the person has also been treated with antibiotics for a month or more. Once they have taken up residence, MARCoNS will further lower MSH (MARCoNS make hemolysin that cleave MSH rendering it inactive), increases cytokines, and lowers T-reg cells resulting in Chronic Fatigue symptoms of body aches and debilitating exhaustion. MARCoNS is commensal colonization that can become an infection. These bacteria send chemicals into the blood and brain (exotoxins A and B) that increase inflammation and by cleaving MSH causes a further decrease of MSH levels, which in turn creates more inflammation. MARCoNS live in the deep nasal passages and is common in all biotoxin illness.
MARCoNS is not commonly found in the deep sinuses of normal individuals with intact immune systems. MARCoNS is found in many patients with mold exposure, chronic Lyme disease, and biotoxin illnesses. As MSH is further lowered by MARCoNS, fatigue and chronic pain due to reduced endorphins and increased cytokines will ensue. In addition, hormone imbalances, mood swings, leaky gut, alternating constipation and diarrhea, lower melatonin (poor sleep), and low ADH (Antidiuretic Hormone) are all the result of low MSH.
When MSH falls too low, the body initially raises ACTH (Adrenocorticotropic Hormone) and Cortisol in response to the increased stress thereby keeping the person functional. However, over time, the body loses the ability to compensate resulting in ACTH and Cortisol values that fall below normal levels and adrenal fatigue sets in. Related to ADH, an imbalance between lowered ADH and Plasma Osmolality (a measure of body hydration) results in the person being unable to hold water (frequent urination) even with increased thirst and may lead to frequent static shocks due to the higher than normal salt levels on the skin, along with lower back pain, fungal overgrowth, depression, allergies, obesity and other symptoms associated with chronic dehydration.
Fungal exposure, chronic Lyme disease, and biotoxin illnesses deplete MSH, often leading to colonization by these bacteria. Staph that is Coagulase Negative has multiple antibiotic resistance usually due to the formation of biofilm which protects the bacteria from the penetration of the antibiotics. In summary, reduced MSH is a co-factor which can lead to MARCoNS becoming a nasal staph infection. MARCoNS activates inflammation and biotoxins.
- Am J Rhinol Allergy. 2012 Mar-Apr;26(2):104-9. doi: 10.2500/ajra.2012.26.3718. Epub 2011 Dec 16.
- Int J Exp Pathol. 2015 Dec; 96(6): 378–386.
- Eur Arch Otorhinolaryngol. 2016; 273: 1989–1994
- Mantovani K, Bisanha AA, Demarco RC, Tamashiro E, Martinez R, Anselmo-Lima WT.Maxilliary sinuses microbiology from patient with chronic rhinosinusitis. Braz J Otorhinolaryngol.2010;76:548–551.
- O'Gara J.P. & Humphreys H. (2001) Staphylococcus epidermidis biofilms: importance and implications. J. Med. Microbiol. 50, 582–587.
- Ramakrishnan V.R., Feazel L.M., Gitomer S.A. et al (2013) The microbiome of the middle meatus in healthy adults.
- Sachse F., von Eiff C., Becker K. et al (2008) Proinflammatory impact of Staphylococcus epidermidis on the nasal epithelium quantified by IL‐8 and GRO‐alpha responses in primary human nasal epithelial cells. Int. Arch. Allergy Immunol. 145, 24–32.
- Pandak N., Pajić‐Penavić I., Sekelj A. et al (2011) Bacterial colonization or infection in chronic sinusitis. Wien. Klin. Wochenschr. 123, 710–713.
- Prince A.A., Steiger J.D., Khalid A.N. et al (2008) Prevalence of biofilm‐forming bacteria in chronic rhinosinusitis. Am. J. Rhinol. 22, 239–245.
- Prokopowicz Z., Marcinkiewicz J., Katz D.R. et al (2012) Neutrophil myeloperoxidase: soldier and statesman. Arch. Immunol. Ther. Exp. (Warsz) 60, 43–54.
- Psaltis A.J., Weitzel E.K., Ha K.R. et al (2008) The effect of bacterial biofilms on post‐sinus surgical outcomes. Am. J. Rhinol. 22, 1–6.
- Otto M (2008) Staphylococcal biofilms. Curr Top Microbiol Immunol 322: 207–228.
- Otto M (2009) Staphylococcus epidermidis - the ‘accidental’ pathogen. Nat Rev Microbiol 7: 555–567.
- Danielsen K.A., Eskeland O., Fridrich‐Aas K. et al (2014) Bacterial biofilms in patients with
- chronic rhinosinusitis: a confocal scanning laser microscopy study. Rhinology 52, 150–155.
- Ferguson B.J. & Stolz D.B. (2005) Demonstration of biofilm in human bacterial chronic rhinosinusitis. Am. J. Rhinol. 19, 452–457.
- Cheung GYC, Rigby K, Wang R, Queck SY, Braughton KR, Whitney AR, et al. (2010) Staphylococcus epidermidis Strategies to Avoid Killing by Human Neutrophils. PLoS Pathog 6(10): e1001133. https://doi.org/10.1371/journal.ppat.1001133
- Fei Da, Hwang-Soo Joo, Gordon Y. C. Cheung, Amer E. Villaruz, Holger Rohde, Xiaoxing Luo, Michael Otto
- Front Cell Infect Microbiol. 2017; 7: 206
- Czekaj T., Ciszewski M., Szewczyk E. M. (2015). Staphylococcus haemolyticus-an emerging threat in the twilight of the antibiotics age. Microbiology 161, 2061–2068. 10.1099/mic.0.000178
- Qin L., Da F., Fisher E. L., Tan D. C., Nguyen T. H., Fu C. L., et al. . (2017). Toxin mediates sepsis caused by methicillin-resistant Staphylococcus epidermidis. PLoS Pathog. 13:e1006153. 10.1371/journal.ppat.1006153
- Banin, Ehud et al. “Chelator-induced dispersal and killing of Pseudomonas aeruginosa cells in a biofilm” Applied and environmental microbiology vol. 72,3 (2006): 2064-9.